Our Research Focus

Gut health is our Passion!

The primary focus area of our research is gastrointestinal function and disorders associated with the gastrointestinal tract.  Our key mission is to develop safe, effective and well-documented products based on scientific research and clinically know-how. 

Our Research Objectives
  • Strengthening existing indications for current products, based on our unique and chemically characterized hydrogel extract.
  • Keeping in step with the current and emerging scientific research, our research also involves investigation of gut microbiota and metabolomic profiles as prediction tools for treatment efficacy.
  • Conducting high-quality research including pre-clinical and clinical studies. All studies are ethically approved and all research activities committed towards publishing in peer-reviewed/medical journals and at medical/scientific congresses.
Research Network

Calmino R&D team collaborates with prominent researchers at the University of Gothenburg, Sahlgrenska University Hospital and Chalmers University of technology, as well as having access to a large knowledge-bank of international scientific competence. Our rich scientific network enables us to be part of the rapidly developing and cutting edge research.

Calmino group strongly believes in “Research being the backbone to a successful and superior product”, which has led the company to sponsor and actively partake in a collaborative  Research Project “Aloe barbadensis Mill. as a therapeutic option for gastrointestinal disorders” in collaboration with Magnus Simren, MD, PhD and Professor Lena Öhman at the University of Gothenburg, Sahlgrenska academy, Sweden. This unique multidisciplinary project also benefits from its collaboration with Associate Professor, Alastair Ross at Chalmers University of technology.

Clinical trials and ongoing research

Our Ongoing Research Projects

Calmino has been a partner in several clinical trials including over 200 participants. Recent clinical trials has aimed at analysing the effects of chemically characterized hydrogel extract on gastrointestinal function, fecal microbiota and fecal metabolite composition in healthy adults in a randomized, double-blind, placebo-controlled studies. 

Other Ongoing Research Projects Include
  • Describing the intestinal microenvironment, combining fecal microbiota and metabolite profiles, in IBS patients (all subtypes) and healthy subjects, and its association to symptoms related to IBS.
  • Comparing the immunosuppressive effect of various Aloe vera extracts (in vitro) and a comprehensive analysis of their bioactive composition.
  • Effect of Aloe vera extract intervention on IBS symptom severity in various IBS subgroups based on bowel habits

Selected publications

Differences in Metabolite Composition of Aloe barbadensis Mill. Extracts Lead to Differential Effects on Human Blood T Cell Activity In Vitro. Ahluwalia B, Magnusson MK, Larsson F, Savolainen O, Ross AB, Öhman L. Molecules. 2022; 27(19):6643.
DOI: https://doi.org/10.3390/molecules27196643

Aloe barbadensis Mill. extract improves symptoms in IBS patients with diarrhoea: post hoc analysis of two randomized double-blind controlled studies. Ahluwalia B, Magnusson MK, Böhn L, Störsrud S, Larsson F, Öhman L, Simrén M.  Therap Adv Gastroenterol. 2021 Oct 8;14:17562848211048133. DOI: https://doi.org/10.1177/17562848211048133 

A Distinct Intestinal Microenvironmental Profile Is Linked To Bowel Habits in Patients with Irritable Bowel Syndrome C. Iribarren,  B. Ahluwalia,  M.K. Magnusson,  J. Sundin,  O. Savolainen,  A. Ross,  H. Törnblom,  M. Simrén, and L.  Öhman UEG Journal October, 2020 DOI: https://doi.org/10.1177/2050640620927345

Randomised Clinical Trial: Effects of Aloe barbadensis Mill. extract on symptoms, fecal microbiota and fecal metabolite profiles in patients with Irritable Bowel Syndrome. Bani Ahluwalia, Maria K. Magnusson, Lena Böhn, Stine Störsrud, Fredrik Larsson, Otto Savolainen, Alastair Ross, Magnus Simrén*, Lena Öhman*; *Shared senior authorship. Neurogastroenterol Motil. April 2020:e13860. DOI: https://doi.org/10.1111/nmo.13860

Immunopathogenesis of inflammatory bowel disease and mechanisms of biological therapies. Bani Ahluwalia, Luiza Moraes, Maria K. Magnusson & Lena Öhman.  Scandinavian Journal of Gastroenterology. 2018; 53:4, 379-389, DOI: https://doi.org/10.1080/00365521.2018.1447597

Mucosal immune system of the gastrointestinal tract: maintaining balance between the good and the bad. Bani Ahluwalia, Maria K. Magnusson & Lena Öhman. , Scandinavian Journal of Gastroenterology, 2017; 52:11, 1185-1193, DOI: https://doi.org/10.1080/00365521.2017.1349173

Effects of Aloe barbadensis Mill. extract (AVH200®) on human blood T cell activity in vitro. Bani Ahluwalia, Maria K. Magnusson, Stefan Isaksson, Fredrik Larsson, Lena Öhman. J Ethnopharmacol. February 2016; 179:301-309. DOI: https://doi.org/10.1016/j.jep.2016.01.003

A Pilot Study of the Effect of Aloe barbadensis Mill. Extract (AVH200(R)) in Patients with Irritable Bowel Syndrome: a Randomized, Double-Blind, Placebo-Controlled Study. Storsrud S, Ponten I, Simren M. J Gastrointestin Liver Dis. 2015; 24(3):275-280. DOI https://doi.org/10.15403/jgld.2014.1121.243.sst