Understanding the mechanisms of a healthy bowel function provides a foundation for optimising targeted interventions for restoring gut health
The gastrointestinal tract is a vital organ that balances two complex and crucial tasks: facilitating digestion and nutrient absorption while maintaining immune homeostasis. This means tolerating harmless elements like food antigens, commensal bacteria, and self-antigens, while mounting effective immune responses against harmful microorganisms.
The intricate balance relies on a highly efficient mucosal barrier and the gut-associated lymphoid tissue (GALT), which coordinates immune responses with remarkable precision. The mechanisms underlying this balance remain unclear, making continuous research essential to deepen our understanding of gut-related disorders
The main focus of our research is to investigate the role of gut microbiota and metabolite production in immune system regulation. The research also explores how immune cells coordinate immune responses in health and disease and examines how diet and external factors affect gut immune homeostasis.
Our research highlights the primary components of the mucosal immune system and their role in coordinating immune responses to tolerate harmless elements like food and commensal bacteria while fighting harmful microorganisms.
Calmino R&D team collaborates with prominent researchers at the University of Gothenburg, Sahlgrenska University Hospital and Chalmers University of technology.
Mucosal immune system of the gastrointestinal tract: maintaining balance between the good and the bad. DOI: https://doi.org/10.108 0/00365521.2017.1349173
Effects of Aloe barbadensis Mill. extract (AVH200®) on human blood T cell activity in vitro. DOI: https ://doi.org/10.1016/j.jep.2016.01.003
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