Investigating the development and progression of inflammatory bowel disease and the potential of targeted therapies
Some facts
What to know about Inflammation
IBS Symptoms
IBS affects the large intestine, causing symptoms like abdominal pain, bloating, gas, and bowel changes.
IBS Triggers
Likely triggered by gut-brain communication issues, gut microbiome changes, and sensitivity in the digestive system.
IBS Treatment
Treatment often involves diet changes, stress reduction, lifestyle adjustments, and medication to relieve symptoms.
IBS Symptoms
IBS affects the large intestine, causing symptoms like abdominal pain, bloating, gas, and bowel changes.
IBS Symptoms
IBS affects the large intestine, causing symptoms like abdominal pain, bloating, gas, and bowel changes.
IBS Symptoms
IBS affects the large intestine, causing symptoms like abdominal pain, bloating, gas, and bowel changes.
Focus
Research area
Infection, inflammation, and immune response
The body is constantly exposed to a vast array of microbes, including bacteria, viruses, fungi, and parasites. The immune system typically responds to infections by initiating inflammation, a protective response designed to eliminate harmful pathogens and repair tissue damage. However, when the immune system overreacts or fails to regulate inflammation properly, it can lead to chronic inflammatory conditions.
Inflammatory diseases
The gastrointestinal tract maintains balance between tolerance to non-pathogenic microbes and protective inflammatory responses against pathogens. Disruption of this balance can lead to inflammatory bowel disease (IBD), a chronic condition that affects millions worldwide.
Progress
Ongoing research
Research goals
Understanding the relationship between inflammation and infection is crucial due to their roles in a wide range of chronic diseases that impact global health.
Studies
Our research focuses on the pathogenesis of inflammation and its role in chronic inflammatory diseases such as IBD. We explore emerging therapies targeting mucosal immunity to improve disease management and therapeutic outcomes.
Collaborations
Calmino R&D team collaborates with prominent researchers at the University of Gothenburg, Sahlgrenska University Hospital and Chalmers University of technology.
Selected publications
Immunopathogenesis of inflammatory bowel disease and mechanisms of biological therapies. DOI: https://doi.org/10.1080/00365521.2018 .1447597
Immunopathogenesis of inflammatory bowel disease and mechanisms of biological therapies. DOI: https://doi.org/10.1080/00365521. 2017.1349173
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